InnovationXLab

THERAPEUTICS AND BIOPRINTING

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THERAPEUTICS

Targeted Antimicrobials and Related Compositions, Methods and Systems (LLNL)

In vitro Assembly, Adhering Cargo to Bacterial Microcompartment Shells (LBNL)

Dynamically-adaptive Live Therapeutic Agents and Methods of Use Thereof (LLNL)

Biomarkers for Predicting Lung Cancer Survival (LBNL)

Novel Human Gene Discovered Responsible for Newborn Diarrhea Disorder (LBNL)

Copolymer Electrolyte Mesh Filtering TACE Therapy Components (LBNL)

Centromere/Kinetochore Protein Genes for Cancer Prognosis, Diagnosis, and Treatment (LBNL)

BIOPRINTING

Omnidirectional, Multiaxial Bioprinted Tissue System, Techniques and Applications (LLNL)

Direct Writing of Tunable Living Inks for Bioprocess Intensification (LLNL)

Polymeric Encapsulation of Whole Cells as Bioreactors (LLNL)
https://str.llnl.gov/2019-07/aines

Bioreactors Including Enzyme-embedded Multi-component Polymers (LLNL)

Participating DOE laboratories and contact information

ANL Argonne National Laboratory
Phil Smith, PESmith@anl.gov

BNL Brookhaven National Laboratory
Poornima Upadhya, PUpadhya@bnl.gov

INL Idaho National Laboratory
Ryan Bills, Ryan.Bills@inl.gov

LBNL Lawrence Berkeley National Laboratory
Robin Johnston, RJohnston@lbl.gov

LLNL Lawrence Livermore National Laboratory
Hannah Farquar, farquar3@llnl.gov

LANL Los Alamos National Laboratory
Marc Steven Witkowski, Witk@lanl.gov

NREL National Renewable Energy Laboratory
Eric Payne, Eric.Payne@nrel.gov

ORNL Oak Ridge National Laboratory
Jennifer Caldwell, CaldwellJT@ornl.gov

PNNL Pacific Northwest National Laboratory
Allan Tuan, Allan.Tuan@pnnl.gov

SNL Sandia National Laboratory
Joel Sikora, JSikora@sandia.gov

These technologies can also be found at the DOE Lab Partnering Service

SYNTHETIC BIOLOGY

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Capabilities and Facilities

The Joint Genome Institute: A DOE User Facility for Genomics-enabled Discovery (LBNL, LLNL)

The Agile BioFoundry: Advanced Tools, Analytics, and Rapid Engineering of Production Microbes (LBNL, SNL, PNNL, NREL, LANL, ORNL, ANL)

Structural Biology and Imaging Resources at Synchrotron and Neutron Facilities (ANL, BNL, LBNL, ORNL, SLAC)

Environmental Molecular Sciences Laboratory (PNNL)

EDGE Bioinformatics: Next Generation Sequencing for Exploring Genomes and Metagenomes (LANL)

National Microbiome Data Collaborative: Microbiome Data Catalog to Enable Discovery and Applications for Energy, Agriculture, Health and Environments (LBNL, LANL, ORNL, PNNL)

KBase: The U.S. Department of Energy Systems Biology Knowledgebase (LBNL, ANL, ORNL)

Software and Tools

CRISPR/Cas9 RNA Editing (SNL)

ART: A Machine Learning Recommendation Tool for Guiding Synthetic Biology (LBNL)

Bacterial Quantitative Trait-Locus Mapping (ORNL

FeatureCreature: An OSS Tool for Structural Visualization of Machine-learned Quantitative Structure Activity Relationships (QSARs) Explanations (SNL)

Jungle Express: Efficient Gene Expression at Negligible Cost (LBNL)

TNT Digestion-Ligation Buffer Formulation (ORNL)

CRAGE: Chassis-independent Recombinase-assisted Genome Engineering: A Universal Approach to Engineer Pathways in a Broad Range of Bacteria (LBNL)

Novel Fungal Auto-inducible Expression System (LBNL)

MAGI: Metabolite, Annotation, and Gene Integration System (LBNL)

BOOST: Build-optimization Software Tools for Redesigning Difficult Nucleotide Sequences for DNA Synthesis (LBNL)

Arrowland: A Multiscale Interactive Tool for Omics Data Visualization (LBNL, SNL)

Microbial and Plant Engineering

Engineered Microbes for Plastic Degradation and Upcycling (NREL)

Transformable Rhodobacter Strains, Method for Producing Transformable Rhodobacter Strains (ANL)

Engineered Photosynthetic Bacteria, Method of Manufacture of Biofuels (ANL)

Creating Synthetic Microbial Consortia (PNNL)

Method and Strain for Sugar Conversion (ORNL)

Synthetic Promoters Useful for Expression in Plant Cells (LBNL)

Agrobacterium-mediated Transformation of Lipomyces (PNNL)

Novel Genes Controlling Cell Wall Biosynthesis (ORNL)

Nanoengineered Membranes for Controlled Transport (ORNL)

Conserved Function between Human and Plant (ORNL)

Fatty Alcohols from Engineered Yeast (LBNL)

Alkyl Lactones from Hydroxy Fatty Acids (LBNL)

Participating DOE laboratories and contact information

ANL Argonne National Laboratory
Phil Smith, PESmith@anl.gov

BNL Brookhaven National Laboratory
Poornima Upadhya, PUpadhya@bnl.gov

INL Idaho National Laboratory
Ryan Bills, Ryan.Bills@inl.gov

LBNL Lawrence Berkeley National Laboratory
Robin Johnston, RJohnston@lbl.gov

LLNL Lawrence Livermore National Laboratory
Hannah Farquar, farquar3@llnl.gov

LANL Los Alamos National Laboratory
Marc Steven Witkowski, Witk@lanl.gov

NREL National Renewable Energy Laboratory
Eric Payne, Eric.Payne@nrel.gov

ORNL Oak Ridge National Laboratory
Jennifer Caldwell, CaldwellJT@ornl.gov

PNNL Pacific Northwest National Laboratory
Allan Tuan, Allan.Tuan@pnnl.gov

SNL Sandia National Laboratory
Joel Sikora, JSikora@sandia.gov

These technologies can also be found at the DOE Lab Partnering Service

PROTEINS/ENZYMES

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Capabilities and Facilities

Environmental Molecular Sciences Laboratory (PNNL)

Structural Biology and Imaging Resources at Synchrotron and Neutron Facilities (ANL, BNL, LBNL, ORNL, SLAC)

Laboratory of Biomolecular Structure — CryoEM Facility (BNL)

PHENIX: Consortium and Software for Computational Crystallography (LBNL)

Scattering Program for Investigating the Structure and Dynamics of Composite and Complex Material, Including Polymers, Films, and Fibers (BNL)

PMedIC: Precision Medicine Innovation Co-Laboratory (PNNL)

Intellectual Property

Engineering Bacterial Systems to Shield Toxicity During Non-native Protein Expression and Purification (LLNL)

Thermoacidophilic Enzyme Systems (INL)

Upcycling Novel Bio-derived Chemical Building Blocks from PET (NREL)

Methods and Devices for Protein Assays (SNL)

NIMS-based Multiplexed Enzymatic Assays (LBNL, SNL)

Cell-Free System for Synthesizing Membrane Proteins (ANL)

Flex Plate: Innovative Protein Crystallization Tool (BNL)

Enzymatic Cascade Bioreactor (SNL)

Armored Enzyme Nanoparticles (PNNL)

Nell1-mediated Regeneration of Skeletal Muscle in Wound Healing and Muscle Dystrophies (ORNL)

A Highly Stable Plant-Fungal Peroxidase Engineered for Enhanced Lignin Conversion (LBNL, SNL)

Improved T7 Cloning and Expression Vectors (BNL)

JTherm Glycoside Hydrolases for Deconstruction of Lignocellulosic Biomass (LBNL, SNL)

Repair of Cardiac Muscles and Blood Vessels Using the Cell Differentiation Signaling Protein Nell1 (ORNL)

Designable Peptoid Nanotubes (PNNL)

Thermophilic Endoglucanase Enzymes Engineered for Increased Activity (SNL)

NanoPOTS: Nanodroplet Processing in One pot for Trace Samples (PNNL)

Broadly pH-tolerant Cellulase Enzymes (LBNL, SNL)

Halophilic and Thermostable Cellulases (LBNL, SNL)

Artificial Metalloproteins for Producing New Chemicals and Materials (LBNL)

Promoter Useful for High Expression of Heterologous Genes in Aspergillus Niger (PNNL, SNL, LBNL)

Identification of Gene Targets for Improved Heterologous Enzyme Production in Aspergillus Niger (PNNL, SNL)

Participating DOE laboratories and contact information

ANL Argonne National Laboratory
Phil Smith, PESmith@anl.gov

BNL Brookhaven National Laboratory
Poornima Upadhya, PUpadhya@bnl.gov

INL Idaho National Laboratory
Ryan Bills, Ryan.Bills@inl.gov

LBNL Lawrence Berkeley National Laboratory
Robin Johnston, RJohnston@lbl.gov

LLNL Lawrence Livermore National Laboratory
Hannah Farquar, farquar3@llnl.gov

LANL Los Alamos National Laboratory
Marc Steven Witkowski, Witk@lanl.gov

NREL National Renewable Energy Laboratory
Eric Payne, Eric.Payne@nrel.gov

ORNL Oak Ridge National Laboratory
Jennifer Caldwell, CaldwellJT@ornl.gov

PNNL Pacific Northwest National Laboratory
Allan Tuan, Allan.Tuan@pnnl.gov

SNL Sandia National Laboratory
Joel Sikora, JSikora@sandia.gov

These technologies can also be found at the DOE Lab Partnering Service

BIOSECURITY

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Analytics for Investigation of Disease Outbreaks (LANL)

Re-emerging Infectious Disease Alert (LANL)

Rapid Detection of Microorganisms (PNNL)

Antibody Profiling (INL)

SpinDx: Point-of-Care Diagnostics Using Centrifugal Microfluidics (SNL)

SmartLAMP: Smartphone-controlled, Battery-operated Point-of-Care Diagnostic Device (SNL)

Computational and Experimental Tools to Detect Engineered Biological Systems and Monitor Their Potential to Spread Disease (ANL)

Uncharged Bis-oximes for Accelerated Reactivation of Organophosphorus-conjugated Human Acetylcholinesterase (ORNL)

PUMA: Ultrasensitive Detection of Biological and Chemical Agents (LBNL)

Methods and Apparatus for Measuring Biofilm Thickness and Topology (PNNL)

Microfluidic Platform for Multiplexed Detection in Single Cells (SNL)

Improved Multidimensional Bioseparation with Modular Microfluidics (SNL)

Preconcentration and Separation of Analytes in Microchannels (SNL)

Hepatitis C Virus (HCV) Database (LANL)

Hemorrhagic Fever Viruses (HFV)/ Ebola Database (LANL)

Methods and Devices for Protein Assays (SNL)

Protein and Nucleic Acid Detection Using Microfluidic Devices (SNL)
US patent application no. 16/399484

Modular Assemblies and Systems for Cell Cultures (SNL)
US patent application no. 15/273,408

Participating DOE laboratories and contact information

ANL Argonne National Laboratory
Phil Smith, PESmith@anl.gov

BNL Brookhaven National Laboratory
Poornima Upadhya, PUpadhya@bnl.gov

INL Idaho National Laboratory
Ryan Bills, Ryan.Bills@inl.gov

LBNL Lawrence Berkeley National Laboratory
Robin Johnston, RJohnston@lbl.gov

LLNL Lawrence Livermore National Laboratory
Hannah Farquar, farquar3@llnl.gov

LANL Los Alamos National Laboratory
Marc Steven Witkowski, Witk@lanl.gov

NREL National Renewable Energy Laboratory
Eric Payne, Eric.Payne@nrel.gov

ORNL Oak Ridge National Laboratory
Jennifer Caldwell, CaldwellJT@ornl.gov

PNNL Pacific Northwest National Laboratory
Allan Tuan, Allan.Tuan@pnnl.gov

SNL Sandia National Laboratory
Joel Sikora, JSikora@sandia.gov

These technologies can also be found at the DOE Lab Partnering Service

BIOMASS DECONSTRUCTION

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Cellulase Formulations (NREL)

Methods and Materials for Deconstruction of Biomass for Biofuels Production (SNL)

Loss of Function Alleles of PtEPSP-TF and Its Regulatory Targets in Rice (ORNL)

Ammonium Based Ionic Liquids for Lignocellulosic Processing (SNL)

C. bescii Cel7A Cellulase (NREL)

One-pot Bioconversion of Distillers Grains to Advanced Biofuels and Chemicals (SNL)

Transcriptional Regulator of MYB46 Expression (ORNL)

Long Alkyl Chain Alcohols as Co-solvent, Precipitant, and Extraction Medium in Ionic Liquid Pretreatment (SNL, LBNL)

Enhanced Processive Cellulases (NREL)

A Serine Hydroxymethyltransferase Regulates Cell Wall Biosynthesis and Recalcitrance in Populus (ORNL)

Sugar Extraction and Ionic Liquid Recycling Using Alkaline Solutions (SNL, LBNL)

C. thermocellum CbhA Cellulase (NREL)

A PtDUF266 Gene Regulating Cell Wall Biosynthesis and Recalcitrance in Populus (ORNL)

Consolidated Conversion of Biomass into Biofuels using Ionic Liquids (SNL, LBNL)

A Laccase Enzyme Regulating Cell Wall Biosynthesis and Recalcitrance in Populus (ORNL)

Recovery of Sugars from Ionic-Liquid Biomass Liquor by Solvent Extraction (LBNL, SNL)

Switchable Ionic Liquids for Biomass Pretreatment and Enzymatic Hydrolysis (SNL)

An EPSP Enzyme which Regulates Phenylpropanoid, Tyrosine and Tryptophan Pathways (ORNL)

Renewable Aromatics from Lignocellulosic Lignin (SNL)

Gene Impacting Cellulose Content and Biomass Formation in Populus (ORNL)

Allelic Variants Regulating Cellulose, Lignin Biosynthesis and Biomass Sugar Yield (ORNL)

A Key Gene Regulating Cell Wall Biosynthesis and Recalcitrance in Populus, Gene Y (ORNL)

Participating DOE laboratories and contact information

ANL Argonne National Laboratory
Phil Smith, PESmith@anl.gov

BNL Brookhaven National Laboratory
Poornima Upadhya, PUpadhya@bnl.gov

INL Idaho National Laboratory
Ryan Bills, Ryan.Bills@inl.gov

LBNL Lawrence Berkeley National Laboratory
Robin Johnston, RJohnston@lbl.gov

LLNL Lawrence Livermore National Laboratory
Hannah Farquar, farquar3@llnl.gov

LANL Los Alamos National Laboratory
Marc Steven Witkowski, Witk@lanl.gov

NREL National Renewable Energy Laboratory
Eric Payne, Eric.Payne@nrel.gov

ORNL Oak Ridge National Laboratory
Jennifer Caldwell, CaldwellJT@ornl.gov

PNNL Pacific Northwest National Laboratory
Allan Tuan, Allan.Tuan@pnnl.gov

SNL Sandia National Laboratory
Joel Sikora, JSikora@sandia.gov

These technologies can also be found at the DOE Lab Partnering Service

BIOFUELS

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Bioenergy Research Centers

The Center for Bioenergy Innovation (ORNL, NREL, and other institutions)

Joint BioEnergy Institute (LBNL, SNL, PNNL, BNL, ANL, and other institutions)

Center for Advanced Bioenergy and Bioproducts Innovation (Led by Univ. of Illinois, Urbana-Champaign and the Carl R. Woese Inst. for Genomic Biology; LBNL, BNL, USDA, and other institutions)

Intellectual Property

Supercritical Solid Catalyst Biodiesel (INL)

Electrochemical Method for Producing a Biodiesel Mixture Comprising Fatty Acid Alkyl Esters and Glycerol (ANL)

Converting Biomass-derived Product to Transportation Fuel Precursors (PNNL)

Modification of Lignin Content of Plant Cell Walls (BNL)

Methods and Materials for Deconstruction of Biomass for Biofuels Production (SNL)

Biosynthesis of Isoprenol: A High-performance Aviation Fuel and Isoprene Precursor (LBNL)

Preparation of Cyclic Acetals for Fuel (LANL)

Ethanol Upgrading to Jet Fuel and Valuable Co-product (ORNL)

Method for Generating Methane from a Carbonaceous Feedstock (ANL)

Altering Plant Lignin Structure for Production of Valuable Industrial Compounds (BNL)

Microbial Production of Sesquiterpenes for High-density Jet Fuel (LBNL)

Terpene Synthases for Biofuel Production and Methods Thereof (SNL)

Hydrothermal Processing of Biomass for Production of Biocrude (PNNL)

Production of Long Chain Hydrocarbons from Biological Sources (LANL)

Engineering an Increase in Ethanol Production by Altering Cofactor Specificity (ORNL)

Bacterial Overproduction of Methyl Ketones from Sugar (LBNL)

Engineered Photosynthetic Bacteria, Method of Manufacture of Biofuels (ANL)

Enrichment of Amino Acids from Biomass Residuum (SNL)
US patent application no. 16/388,385

Liquid Hydrocarbons from Biomass-derived Ethanol (ORNL)

GREET Model for Fuel and Vehicle Technology LCA (ANL)

Biochemical Upgrading of High-protein Biomass and Grain Products (SNL)
US patent application no. 15/447,567

Co-fermentation of Microorganisms Cooperative for Biomass Conversion (ORNL)

Bio-based Bisabolene: Diesel or Jet Fuel Additive with a Very Low Cloud Point (LBNL)

Gene Deletion to Increase Ethanol Production in Clostridium thermocellum (ORNL)

Octane Hyperboosting in Fuel Blends (SNL)
US patent application no. 16/438,763

Biohydrogen Production by an Artificial Enzymatic Pathway (ORNL)

AltSim: Alternative Liquid Fuels Simulation Model (SNL)

Synthesis of Fuels and Feedstocks (LANL)

Participating DOE laboratories and contact information

ANL Argonne National Laboratory
Phil Smith, PESmith@anl.gov

BNL Brookhaven National Laboratory
Poornima Upadhya, PUpadhya@bnl.gov

INL Idaho National Laboratory
Ryan Bills, Ryan.Bills@inl.gov

LBNL Lawrence Berkeley National Laboratory
Robin Johnston, RJohnston@lbl.gov

LLNL Lawrence Livermore National Laboratory
Hannah Farquar, farquar3@llnl.gov

LANL Los Alamos National Laboratory
Marc Steven Witkowski, Witk@lanl.gov

NREL National Renewable Energy Laboratory
Eric Payne, Eric.Payne@nrel.gov

ORNL Oak Ridge National Laboratory
Jennifer Caldwell, CaldwellJT@ornl.gov

PNNL Pacific Northwest National Laboratory
Allan Tuan, Allan.Tuan@pnnl.gov

SNL Sandia National Laboratory
Joel Sikora, JSikora@sandia.gov

These technologies can also be found at the DOE Lab Partnering Service

BIO-BASED CHEMICALS, INTERMEDIATES, POLYMERS, AND MATERIALS

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Bioproducts, Sciences, and Engineering Lab (PNNL)

RetSynth: Retrobiosynthesis Tool (SNL)

Bio-derived Acrylonitrile for Renewable Carbon Fiber (NREL)

Polyketide Synthases Portfolio for Production of a Wide Range of Chemicals and Polymer Precursors (LBNL)

Flame Resistant Wood Treatment Resins (INL)

Biomimetic Materials for Protein Storage and Transport (ANL)

Desaturase Genes for Improved Plant Seed Oils (BNL)

Engineered Microbes for the Conversion of Lactic Acid to Butyric Acid (ORNL)

Renewable Unsaturated Polyesters and Resins (NREL)

Renewable Chemical Feedstock (BNL)

High Titer Production of the Blue Dye Indigoidine in Rhodosporidium toruloides (LBNL, SNL)

Method for the Preparation and Production of Carbon Fiber from Biomimetic Fiber Precursor and Carbon Fibers Made Thereby (ORNL)

Biomimetic Membranes (SNL)

Biomimetic Gas-permeable Membranes (SNL)

Converting Bio-based Ethanol to High Value Ketones (PNNL)

Method of Controlling Particle Size of Inorganic Nanoparticles in a Fermentation Process (ORNL)

Biomass to Nylon (NREL)

Biosynthetic Production of 2-Pyrrolidone, a Building Block for Pharmaceuticals and Nylon-4, and a Multiple-use Solvent (LBNL)

Binary Cultivation in Photobioreactors (PNNL)

Renewable Polyurethanes (NREL)

Enzymatic Activation and Cyclization of Hydroxy Fatty Acids for the Production of Alkyl Lactones (LBNL)

Fatty Alcohols from Engineered Yeast (LBNL)

Scaling Cellulose Nanocrystals at Argonne’s Materials Engineering Research Facility (ANL)

Producing the Antioxidant Hydroxytyrosol in Engineered Microbial Hosts (LBNL)

Production of Dicarboxylic Compounds from Renewable Sources (LBNL)

Lignin Valorization

Genetically Modified Lignin-derived Bio-thermoplastics for Polymer Matrix Composites (ORNL)

Altering Plant Lignin Structure for Production of Valuable Industrial Compounds (BNL)

Lignin Nanoparticle Synthesis (SNL)

Lignin-based 3D Printing Material (ORNL)

Functionalized Lignin, Rubber Containing Functionalized Lignin (SNL)

Enzymatic Pathway for Conversion of a Model Lignin Linkage (ORNL)

Production of Itaconic Acid and Related Molecules from Aromatic Compounds (ORNL)

Filamentous Fungi Capable of Degrading and Utilizing Lignocellulosic Wastes (ORNL)

Sustainable Composites of Lignin-based Recycled Plastics (ORNL)

Renewable Aromatics from Lignocellulosic Lignin (SNL)

Participating DOE laboratories and contact information

ANL Argonne National Laboratory
Phil Smith, PESmith@anl.gov

BNL Brookhaven National Laboratory
Poornima Upadhya, PUpadhya@bnl.gov

INL Idaho National Laboratory
Ryan Bills, Ryan.Bills@inl.gov

LBNL Lawrence Berkeley National Laboratory
Robin Johnston, RJohnston@lbl.gov

LLNL Lawrence Livermore National Laboratory
Hannah Farquar, farquar3@llnl.gov

LANL Los Alamos National Laboratory
Marc Steven Witkowski, Witk@lanl.gov

NREL National Renewable Energy Laboratory
Eric Payne, Eric.Payne@nrel.gov

ORNL Oak Ridge National Laboratory
Jennifer Caldwell, CaldwellJT@ornl.gov

PNNL Pacific Northwest National Laboratory
Allan Tuan, Allan.Tuan@pnnl.gov

SNL Sandia National Laboratory
Joel Sikora, JSikora@sandia.gov

These technologies can also be found at the DOE Lab Partnering Service

BIOMANUFACTURING AT SCALE

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Facilities and Consortia

Integrated Biorefinery Research Facility: Development and Testing of Biochemical Conversion Technologies at up to 9000L Scale (NREL)

Feedstock-Conversion Interface Consortium: Improving Biorefinery Operations by Understanding Biomass Properties (INL, ORNL, PNNL, ANL, NREL, LANL, SNL, LBNL)

Biomass Feedstock National User Facility (INL)

Bioenergy Feedstock Library (INL)

Thermal and Catalytic Process Development Unit (NREL)

Advanced Biofuels and Bioproducts Process Development Unit: Scaling Bioconversion Innovation from the Lab to Commercial Relevance (LBNL)

Bioprocessing Separations Consortium: Biocatalyst Preservation, Algae Processing, and Biochemical and Thermochemical Conversion (ANL, LBNL, LANL, NREL, ORNL, PNNL)

Process Development Units for Hydrothermal Liquefaction, Catalytic Hydrothermal Gasification, and Upgrading (PNNL)

Chemical Catalysis for Bioenergy Consortium: Overcoming Catalysis Challenges in the Conversion of Biomass to Fuels and Chemicals (NREL, PNNL, ORNL, NETL, LANL, ANL, SNL, INL)

Separations

Bioprocesses and Reactive Separations Capabilities (ANL)

Airfoil-shaped Micro-Mixers for Reducing Fouling on Membrane Surfaces (SNL)

Switchable Polarity Solvent — Forward Osmosis (INL)

Flowthrough Pretreatment of Lignocellulosic Biomass with High-Temperature Nanoporous Membranes for Selective Separations (ORNL)

EZ Select: Superior Separations Technology for More Effective and Cost-Efficient Biomanufacturing (ANL)

Switchable Antifouling Coatings (SNL)

Porous Solid Ion Exchange Wafer for Immobilizing Biomolecules (ANL)

Single-stage Separation and Esterification of Cation Salt Carboxylates Using Electrodionization (ANL)

Electrodeionizing Method (ANL)

Retention of Counterions in the Separative Bioreactors (ANL)

Electronically and Ionically Conductive Porous Material and Method for Manufacture of Resin Wafers Therefrom (ANL)

Bioprocess Utilizing Carbon Dioxide and Electrodeionization (ANL)

Methane Production Using Resin-Wafer Electrodeionization (ANL)

Ordered Nanoscale Domains by Infiltration of Block Copolymers (ANL)

Functionalized Foams (ANL)

Sequential Infiltration Synthesis (SIS) for Robust Filtration Membranes (ANL)

Janus Membranes by Atomic Layer Deposition (ANL)

Biomass Handling

Low Energy Biomass Densification Process (INL)

Process for Accurate Characterization of Bulk Solids Flow (INL)

Adaptive Control System for Biomass Material Handling (INL)

Participating DOE laboratories and contact information

ANL Argonne National Laboratory
Phil Smith, PESmith@anl.gov

BNL Brookhaven National Laboratory
Poornima Upadhya, PUpadhya@bnl.gov

INL Idaho National Laboratory
Ryan Bills, Ryan.Bills@inl.gov

LBNL Lawrence Berkeley National Laboratory
Robin Johnston, RJohnston@lbl.gov

LLNL Lawrence Livermore National Laboratory
Hannah Farquar, farquar3@llnl.gov

LANL Los Alamos National Laboratory
Marc Steven Witkowski, Witk@lanl.gov

NREL National Renewable Energy Laboratory
Eric Payne, Eric.Payne@nrel.gov

ORNL Oak Ridge National Laboratory
Jennifer Caldwell, CaldwellJT@ornl.gov

PNNL Pacific Northwest National Laboratory
Allan Tuan, Allan.Tuan@pnnl.gov

SNL Sandia National Laboratory
Joel Sikora, JSikora@sandia.gov

These technologies can also be found at the DOE Lab Partnering Service

ALGAE

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Capabilities and Facilities

DISCOVR: Development of Integrated Screening, Cultivar Optimization, and Verification Research Consortium: Enhancement of Algae Productivity and Cultivation (LANL, NREL, PNNL, SNL)

Biofuels Scientific Focus Area (LLNL)

Marine Sciences Laboratory (PNNL)

Algae Pond Real-time Monitoring and Diagnostics (SNL)

High-Throughput Genetic Testing for Algae (BNL)
For information contact Ann Emrick at emrick@bnl.gov

Greenhouse: An Omics Knowledgebase for Algal Feedstocks (LANL)

NOMAD: Nautical Offshore Autonomous Device for Cultivating Macroalgae (PNNL)

LEAPS: Laboratory Environmental Algae Pond Simulator Mini-photobioreactors (PNNL)

Environmental Photobioreactor Matrix (LANL)
For information contact Taraka Dale at tdale@lanl.gov

Intellectual Property

Renewable Polyurethanes (NREL)

Process for the Stabilization of Stored Algae (INL)

Enhanced Production of Biofuel Precursors in Microalgae (LBNL)

Cyanobacterial Production of Ethylene (NREL)

High-rate Periphytic Algae Flow-way (SNL)

Scaffolds for Growing Algal Biomass (SNL)
US patent application no. 62/613,637

Enzymatic Degradation of Algal Cell Walls (NREL)

Crop Protection in Microalgae by Terpene Expression (SNL)

Biochemical and Thermochemical Conversion of Algae (SNL)

ABCLAT: Algae Biofuels Co-Location Assessment Tool (SNL)
For information contact Tristan Mahyera at tmahyer@sandia.gov

A-SHARP: Analysis-Software for Hyperspectral Algal Reflectance Probes (SNL)
For information contact Tristan Mahyera at tmahyer@sandia.gov

Participating DOE laboratories and contact information

ANL Argonne National Laboratory
Phil Smith, PESmith@anl.gov

BNL Brookhaven National Laboratory
Poornima Upadhya, PUpadhya@bnl.gov

INL Idaho National Laboratory
Ryan Bills, Ryan.Bills@inl.gov

LBNL Lawrence Berkeley National Laboratory
Robin Johnston, RJohnston@lbl.gov

LLNL Lawrence Livermore National Laboratory
Hannah Farquar, farquar3@llnl.gov

LANL Los Alamos National Laboratory
Marc Steven Witkowski, Witk@lanl.gov

NREL National Renewable Energy Laboratory
Eric Payne, Eric.Payne@nrel.gov

ORNL Oak Ridge National Laboratory
Jennifer Caldwell, CaldwellJT@ornl.gov

PNNL Pacific Northwest National Laboratory
Allan Tuan, Allan.Tuan@pnnl.gov

SNL Sandia National Laboratory
Joel Sikora, JSikora@sandia.gov

These technologies can also be found at the DOE Lab Partnering Service

AI, MACHINE LEARNING, AND ANALYTICS

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The Agile BioFoundry: Advanced Tools, Analytics, and Rapid Engineering of Production Microbes (LBNL, SNL, PNNL, NREL, LANL, ORNL, ANL)

AI-enabled Subfield Crop Yield Prediction (INL)

Scenario-driven Data Modelling (ORNL)

ISiCLE: In Silico Chemical Library Engine for High-Accuracy Chemical Property Prediction (PNNL)

BioCompoundsML: A Tool for Screening Compounds for Fuel and Chemical Properties (SNL)

ART: A Machine Learning Recommendation Tool for Guiding Synthetic Biology (LBNL)

Omics Open Source Software (PNNL)

Computational Mass Spectrometry Software (PNNL)

AR1K Project: Academics and Industry Collaborating to Revolutionize Agriculture Using Biology, Biogeochemistry, Sensing Technologies, and Third-wave, Explainable AI (LBNL)

GenSig: Genetic Signatures in a DNA alignment with Associated Phenotypic Data (LANL)

MAGI: Metabolite, Annotation, and Gene Integration System (LBNL)

PrimerDesign: M-Finding Primers for PCR & Sequencing (LANL)

CasCollect: A Tool for Identifying Cas Operons from Next Gen Sequencing and Assembled Genomes (SNL)

Pixel: Amino Acid and DNA Imaging (LANL)

LIQUID: Lipid Informed Quantification and Identification Software (PNNL)

Optimizing Neural Networks (ORNL)

MENNDL: Multinode Evolutionary Neural Networks for Deep Learning (ORNL)

Analytics for Investigation of Disease Outbreaks (LANL)

Infectious Disease-related Tools

Re-emerging Infectious Disease Alert (LANL)

HIV Database (LANL)

CATNAP: Compile, Analyze, and Tally Nab Panels (LANL)

RAPR: Recombination Analysis Program (LANL)

Epigraph: Vaccine Design Tool (LANL)

Hepatitis C Virus (HCV) Database (LANL)

Participating DOE laboratories and contact information

ANL Argonne National Laboratory
Phil Smith, PESmith@anl.gov

BNL Brookhaven National Laboratory
Poornima Upadhya, PUpadhya@bnl.gov

INL Idaho National Laboratory
Ryan Bills, Ryan.Bills@inl.gov

LBNL Lawrence Berkeley National Laboratory
Robin Johnston, RJohnston@lbl.gov

LLNL Lawrence Livermore National Laboratory
Hannah Farquar, farquar3@llnl.gov

LANL Los Alamos National Laboratory
Marc Steven Witkowski, Witk@lanl.gov

NREL National Renewable Energy Laboratory
Eric Payne, Eric.Payne@nrel.gov

ORNL Oak Ridge National Laboratory
Jennifer Caldwell, CaldwellJT@ornl.gov

PNNL Pacific Northwest National Laboratory
Allan Tuan, Allan.Tuan@pnnl.gov

SNL Sandia National Laboratory
Joel Sikora, JSikora@sandia.gov

These technologies can also be found at the DOE Lab Partnering Service

AGRICULTURE

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Capabilities and Facilities 

Greenhouses and Controlled Growth Chambers (BNL)
For information contact Justin Andrews

Field Testing Facilities (BNL)
For information contact Justin Andrews

In Vivo Molecular Imaging for Agriculture and Plant Engineering (JLab)

Microbial Systems and Communities Research (ANL)

National Microbiome Data Collaborative: Microbiome Data Catalog to Enable Discovery and Applications for Energy, Agriculture, Health and Environments (LBNL, LANL, ORNL, PNNL)

EcoFAB Initiative: Fabricated Ecosystems for Higher-throughput, Standardized Studies of Soil- Microbe-Plant Interactions (LBNL)

AR1K Project: Academics and Industry Collaborating to Revolutionize Agriculture Using Biology, Biogeochemistry, Sensing Technologies, and Third-wave, Explainable AI (LBNL)

Intellectual Property

AI-enabled Subfield Crop Yield Prediction (INL)

Genes Regulating Plant Regeneration (ORNL)

Synthetic Promoters Useful for Expression in Plant Cells (LBNL)

Transcriptional Regulator of Phosphoenolpyruvate Shunt between Shikimate and Glycolysis Pathways (ORNL)

Improving Photosynthesis by Eliminating a Sustained Photoprotective Mechanism (LBNL)

Gene for Enhancing Salt and Drought Tolerance in Plants (ORNL)

Novel Peptide Capable of Stimulating Disease Resistance in Plants (LBNL)

Genes for Enhancing Drought and Heat Tolerance in Plants, and Methods of Use (ORNL)

Identification of Plant Metabolites that Induce Plant Disease Resistance and Plant Defenses (ORNL)

Gene Modification to Increase Drought and Flood Tolerance in Plants (LBNL)

Use of Cholinium Lysinate as a Low-persistence, Low-toxicity Herbicide (LBNL)

Artificial Positive Feedback Loop for Controlled Gene Expression and Bioproduction in Plants (LBNL)

Engineering Competitive Pathways for Tissue-specific Lignin Reduction (LBNL)

Tissue-specific Lignification Stoppers (LBNL)

Biological Production of Muconic Acid in Plants (LBNL)

Intellectual Property: Soil Microbiome

Association Nitrogen-fixing Bacterium/Mycorrhizal Fungus to Enhance Nitrogen Nutrition in Plant (ORNL)

Complex of Mutualistic Microbes Designed to Increase Plant Productivity (ORNL)

Genetic Consortia Mediating Resistance to Septoria Pathogen (ORNL)

Inhibiting Growth of Diverse Bacteria and Plant Pathogens (LBNL)

A Protein Domain Modulating Host-Cell Invasion (ORNL)

Plant Growth Promoting Rhizobacterium (ORNL)

A Lectin-like Receptor Kinase Leads to Enhanced Mycorrhization in Plants (ORNL)

Participating DOE laboratories and contact information

ANL Argonne National Laboratory
Phil Smith, PESmith@anl.gov

BNL Brookhaven National Laboratory
Poornima Upadhya, PUpadhya@bnl.gov

INL Idaho National Laboratory
Ryan Bills, Ryan.Bills@inl.gov

JLAB Jefferson Lab
Deborah Dowd, Dowd@jlab.org

LBNL Lawrence Berkeley National Laboratory
Robin Johnston, RJohnston@lbl.gov

LLNL Lawrence Livermore National Laboratory
Hannah Farquar, farquar3@llnl.gov

LANL Los Alamos National Laboratory
Marc Steven Witkowski, Witk@lanl.gov

NREL National Renewable Energy Laboratory
Eric Payne, Eric.Payne@nrel.gov

ORNL Oak Ridge National Laboratory
Jennifer Caldwell, CaldwellJT@ornl.gov

PNNL Pacific Northwest National Laboratory
Allan Tuan, Allan.Tuan@pnnl.gov

SNL Sandia National Laboratory
Joel Sikora, JSikora@sandia.gov

These technologies can also be found at the DOE Lab Partnering Service